Tawing, dehydrating, and astringent product



Patented Dec. 20, 1932 UNITED STATES- HAROLD mm NOLAN, OF NEW YORK, N. x'.-, s sIGNoR or ONE-HALF r0 summon ELLIS, or MONTGLAIR, NEW JERSEY TAWING, DEHYDRATING, nnnns'mmcnnr PRoD'Uc'r l rawing.

This invention relates to products for application to the surface of animal tissues to procure tawing, antiseptic, astringent, anhidfSiic, or coagulant effects.

These new products consist of solutions of suitable organic or mixtures of organic and inorganic salts of metals, such as zinc and aluminum, whose soluble salts are astringent, in suitable organic liquids, mixed with water.

19 The salts are chosen so as to remain in solution in the mixture of organic liquid and water in the conditions of use. Such salts are, for example, aluminum acetate, aluminum chloride, zinc acetate, zinc paraphenolsulphonate. When mixtures of salts are used the latter must be so chosen that no precipitation by double decomposition can occur.

The organic liquid must be miscible with water, Volatile at ordinary temperatures,

penetrant to animal tissues and solvent of the salt or salts used, or, at least, not capable of throwing these out of their aqueous solution, to a substantial degree, in the conditions of use. These conditions are fulfilled by acetone, methanol, ethanol, propanol and isopropanol, in their various commercial forms, as well as by mixtures of these. In any given case the choice of organic liquid must depend on the special conditions, notably on the nature of the salt in use, on the degree of dilution contemplated and on the temperature.

The following is an example of one composition of the kind described (parts by weight) Part6s Aluminum acetate A Water To this solution add: isopropanol, to make 40 100 parts.

The following is another example Add the ethanol to the aluminum chloride solution and at or I mix in the aluminum acetate solution.

by their ready volatility they facitate drying skin.

Application filed February 24; 1926. SerialjNo; 96,427.

The advantages claimed for-thesecompositions are several. In the first place, the surfaces'of animal tissues are usually somewhat repellent. to plain aqueous" solutions of these salts and are not readily evenly. wetted nor well penetrated by them.- The organic fluids cause the surface of the tissuesto be evenly wetted by the solutions and by their strong penetrating power carry the salts belowthe surface. In thesecond place, these organic liquids Pbeing themselves dehydrants, coagulants' and antiseptics, act as powerful ad- 'juvants to the astringent metallic salts with which-they are associated. In the third place,

of the surface, which with thei'r'dehydrating property, eliminates certain desirable functions of 'simple aqueous solutions. In the fourth place, the alcohols tend to depress the formation in such solutions iof free acid re- -'sulting from j hydrolytic dissociation of the metallic "salt." In the case of the mixture of or'ganicand inorganic salt (such as the mixture containing the chloride and the ace tate) thereis the further advantage that any such free acid will. be relativelyweak organic acid while the high solubility of the inorganic constituent permits of the utilization of strong solutions. Experiment has shown that such solutions are stable, and that, even on heating, 'littleif any free acid is given off. This may be due to esterification. This point 'is of especial importance where the use of the solutions brin gs them in contact with human The proportion of metallic salt should be between 5 per cent and 25 per cent by weight,

depending on the salts used andon the purpose for which the solution is to be employed. The organic liquid penetrant may constitute from not less than 15 to not more than 50 per cent by weight. In the case of the more volatile organic penetrants, it has been found advantageousto use. the higher percentages, to counterbalance the rapid loss by evaporation.

While I have spoken especially of the acetate and chloride of aluminum, I do not preclude myself from the useof other salts and mixtures, each in its suitable applications. For example my invention covers solutions 9 made with the other halides of aluminum, as well as the lactate, the citrate, the tartrate of the same metal, the salts of the lower fatty acids with aluminum and mine, the nitrates of aluminum and zinc and the salicylate of ZlIlC.

It is animportant "characteristic of these stable compositions that, when applied to animal membranes, they do not segregate in uniformly.

What I claim is a 1. A stable composition comprising an aluminum salt dissolved -in aliquid containing volatile alcoholic material,the concentration of the salt being:between Z5 and 25% by weight of the composition; said composition yielding at continuous 'film without segregating into irregular .oily patches 1011 :application to animal membrane.

2. FA liquid composition icomprising alu- Iriinum acetate, water and alcohol.

3. A zliquid (composition ncomprising .za-luminum' acetate,: aluminum chloride,'water: and alcohol.

'4. A composition comprising 1311 ,aqueous solution of :aluminum chloride stabilized by aluminum actatezand'ethyl alcohol.

"5. :A composition comprising :an -zaque0.11s alcoholic solution of-aluminum chloride and -arvorganic salt of aluminum.

6. :A liquidzcomposition comprising-armamminum compoundhaving an astringent action on animal tissues, dissolved. in water :andz-a Water miscible vliquid-organic solvent volatile at ordinary 2 temperatures and; possessing :the power of I penetrating animal tissues.-

7. -A stable composition. comprisingianraluminum' saltdissolved -in a: liquidrcontaining water and a volatile valcoholic .inateriahsth'e concentration'o'f the salt being between- Errand 915%; by-weightofi the composition ;-.sai'd.= composition yielding a continuous film without segregation into irregular oily ;patches .on application to animal membrane.

a '8. L'Awstablecomposition comprising-1a -:-w.a-

tor-soluble aluminum: salt *:and dissolved in liquid volatile material selected fromtthe group includingiacetoneandmnaliphatic-alcohol containing not more than 4 carbon atoms.

9. illiquid composition comprising analumin-um compound having-am astringentaaetion onan-imal' tissues,dissolvedinswateruand a w atervmiscible' liquid organic solvent volatile :at ordinary temperaturesland possessing the power of penetrating animal tissues said organicsolvent being selected from thegroup including acetone Bll'ldkfill aaliphatiosalcohol contain-ingnot mOIeith3I114: carbon atoms.

HAROLD OMAR NQDAN.

CERTIFICATE OF CORRECTION.

Patent No. 1,891,440. December 20, 1932.

HAROLD OMAR NOLAN.

It is hereby certified that error appears in the printed specification of the above numbered patent requiring correction as follows: Page 1, line 67, after "curtain" insert "less"; and that the said Letters Patent should be read with this correction therein that the same may conform to the record of the case in the Patent Office.

Signed and sealed this 24th day of October, A. D. 1933.

F. M. Hopkins (Seal) Acting Commissioner of Patents. 

